Forget about Spanish Fly, Maca, Ginseng and Oysters - PT-141 is an ACTUAL aphrodisiac

All is not penis enlargement, and penis enlargement is not all. Having a bigger penis will not automatically improve one's sex life. This post is about sexual wellness and a treatment for low sexual desire syndrome - particularly in females, and particularly in premenopausal and menopausal women, but also for men who have a hard time getting really aroused - for instance men suffering from depression. You will learn about the new FDA-approved medicine Vyleesi, which began as a research peptide called PT-141, sold under the brand name Bremelanotide. It is an actual working modern medical miracle - an aphrodisiac which works, without the severely addictive properties of party drugs like MDMA or Cocaine (which are both potent aphrodisiacs, but also schedule 1 drugs for a reason). 

 

Traditional Aphrodisiacs

There are hundreds of traditional herbs and supplements used as aphrodisiacs - some of them useless, some of them with small but useful effects.

 

The "Spanish Fly" is actually a beetle (Lytta Vesicatoria). These beetles synthesise cantharidin, a toxic compound that causes irritation and swelling of the urinary tract, which can be misconstrued as sexual arousal. Historically, it has been used as an aphrodisiac, but its use is highly dangerous. Cantharidin is toxic and can cause severe gastrointestinal and urinary tract irritation, leading to potentially fatal outcomes. Avoid! Thankfully - most "Spanish Fly" pills and potions don't actually contain any ground up beetle...

 

Oysters have a long-standing reputation as aphrodisiacs, attributed partly to their high zinc content. Zinc is important for testosterone production and reproductive health, which might possibly contribute to their reputation. Testosterone of course plays a key role in libido in both men and women (yes, women have testosterone too, but less so than men), and deficiencies in zinc can lead to decreased testosterone levels, affecting sexual desire. Moreover, oysters contain certain amino acids like D-aspartic acid and N-methyl-D-aspartate, which have been found to increase levels of sex hormones in rats and could potentially have similar effects in humans. But frankly, I think it's more the fact that they taste vaguely like a vagina and their labia-like shape and consistency which gives them their reputation. 

 

Ginseng, particularly Panax ginseng, often called Korean red ginseng, has been utilised in traditional Chinese medicine for centuries. Research suggests it may improve sexual function in men, possibly due to its effects on neurotransmitter pathways involved in sexual arousal. Chalk it up as "possibly slightly aphrodisiac". 

Maca is a root vegetable native to the Andes Mountains, which has been used by the indigenous people of Peru to boost libido and increase endurance. Studies have shown mixed results, but some suggest it might have a positive effect on sexual desire and may alleviate sexual dysfunction. Might actually work a little. 

Yohimbine is derived from the bark of the African yohimbe tree, and has been used to treat erectile dysfunction. Yohimbine works primarily by increasing the release of noradrenaline and blocking alpha-2 adrenergic receptors. Alpha-2 receptors typically act to inhibit the release of noradrenaline. It's thought to work by increasing blood flow and nerve impulses to the penis or vagina. However, yohimbine can have significant side effects and interactions with other medications. It can negatively affect your blood pressure or cause insomnia. Use with caution. 

Tribulus terrestris is used in Ayurvedic and Chinese medicine and has been claimed to increase testosterone levels, thereby improving sexual desire and performance. However, scientific evidence supporting these effects is limited. Don't waste your money. 

 

I could make this list longer - a lot longer - but what these compounds have in common is that their effects are not very strong, and some of them might work, but on very long time frames - weeks or months. 

 

Enter modern medicine

It should come as no surprise to regular readers that I am a man of science. One thing I really enjoy reading about, is serendipitous scientific discoveries where scientists more or less stumble on new medicines while trying to cure something completely different. 

 

Viagra was one such serendipitous discovery. It was developed to treat angina pectoris - chest pain due to coronary heart disease - by causing vasodilation. It's said that when time came for patiens in the early trials to hand back left over pills, the men were reluctant to do so, and when asked why, it came out that they thought the pills improved their sexual function, and so the research took a different direction. It might be a myth, but it's a fun story. It's true that the effect on erections was discovered by accident though. However, Viagra is not an aphrodisiac. It helps with blood flow, but doesn't make you horny. 

 

PT-141, the main protagonist in this post, has a very similar genesis story to Viagra. It began as a possible candidate to treat Vitiligo. It was initially researched as a possible sunless tanning agent due to its melanocyte-stimulating properties (the cells which produce melanin, which is the dark brown pigment in our skin and eyes). It is a synthetic peptide analogue of the naturally occurring hormone alpha-MSH (melanocyte-stimulating hormone). During early trials of its predecessor compound, melanotan II, which was being studied for its effects on skin tanning, an unexpected side effect was observed: sexual arousal and spontaneous erections in male subjects. And I mean... it wasn't just a little - there were some wild stories...

 

The discovery of these sexual effects prompted further research specifically into the compound's potential as a treatment for sexual dysfunction. Unlike Viagra and other PDE5 inhibitors that work by enhancing blood flow to the genitals, PT-141 acts on the central nervous system. It binds to melanocortin receptors in the brain, particularly the MC4R, involved in sexual arousal and erectile function. This unique mechanism of action makes PT-141 effective in treating sexual dysfunction for both men and women, including erectile dysfunction in men and hypoactive sexual desire disorder (HSDD) in premenopausal women.

 

PT-141's development reflects the phenomenon of drug repositioning, where compounds initially designed for one purpose are found to have beneficial applications in other areas. After further clinical trials focused on its effects on sexual arousal and desire, bremelanotide (PT-141) was approved by the FDA in June 2019 for the treatment of HSDD in premenopausal women. Its approval marked it as the first medication of its kind, addressing a significant unmet need in the treatment of female sexual dysfunction by targeting the central nervous system rather than the vascular system. For women it's often not the vascular system of the vaginal canal and clitoris that's the problem - it's what the drop in hormones does to the brain - namely that hypoactive sexual desire syndrome. It's believed that a large number of divorces that happen after women enter premenopause are actually to a great extent caused by this sudden loss of sexual interest. And women as a rule really miss it, when they lose it. Just as depression can cause loss of sexual interest, the opposite is also true - a loss of sexual interest can cause depression and general lack of drive.

 

Sadly, PT-141 is not yet approved for treatment of men. Hypoactive sexual desire disorder exists in men too - but it's not as well studied, and for some reason people seem to care less that men suffer from such things. Male sexual desire has always been both celebrated and deemed suspicious if not downright dangerous. 

 

Ok, ok... enough... get to the heart of the matter already! How does it feel? 

 

Storytime!

Well, now we get to my little anecdote. My wife and I tried it recently, and it was interesting, to say the least. 

 

My wife is in late premenopause. Many months go by without a period, and then one or two small ones happen, then nothing again, etc. About a year ago, she noticed she was starting to develop sexual dysfunction. When she masturbates, it takes her forever to orgasm, even with the massaging shower head that's hear favourite tool, and even with the Doxy Magic Wand - these are hard hitters, folks. Whereas before I could always make her orgasm three times or more during sex, now she was happy to manage one small one. 

 

L-Citrulline and Arginine have been tremendously good for her. They help her clit get erect even though signals from the brain are weaker now. Another thing that has helped is E-Stim devices (electrosex being a hobby of ours - we are very adventurous), which can help her brain come on line and connect with her genital region. But even with these aids, which gave her back some of the multiple orgasms of old, things just were not the same for her. 

 

So, I did my research and dug up PT-141 and read up on it in great depth. With my background as a brain scientist - (doesn't that sound pretentious - I took a few courses at university and have kept up, but never worked actively in the field) - I have always enjoyed reading about the signalling systems we don't hear about quite as often; the opioid receptors, cannabinoid receptors, the glutamate- and GABA systems, etc. Melanocortins are perhaps more obscure than all of these - recondite stuff. 

 

Sadly, Bremelanotide / Vyleesi / PT-141 is not available as a prescription drug in Europe. It's only sold in the US, and only marketed to women in premenopause who have HSDD. So, I ordered a vial and an injection pen from a SARMS shop in Britain. You know, one of those shops where people buy steroids and research chemicals "not for human use". Note: I will not tell you where, not even in a private message. Do your own sourcing, this is not the place to ask. 

 

My wife took 1.85 milligrams of PT-141 as a subcutaneous injection about an hour before I came home and did the same. We both took our usual L-Citrulline, and I had taken my usual daily Cialis the night before. Then we took a hot soak in the bathtub and waited for things to happen. 

 

I must say, 45 minutes was not sufficient time for the substance to work for me, that I could notice. But for my wife, who had taken it an hour earlier, it was another matter entirely. Lord almighty, she was back to her old form. Her brain and clit linked up, and the multiple orgasms were back in full force. It was easy for her, and she was so happy about that, she actually had a little cry about it after. 

 

But for my own part, it hadn't had time to work yet. I enjoyed myself, but not more than usual. 

 

Later that day though... wow! I did some chores around the house and took some trash to the recycling centre, and felt a little sick - not quite to where I had to throw up, but enough to where there was some unease - and when I came back home, my wife gave me an embarrassed smile and whispered (our kids were home by this time) that she had been having constant contractions for hours. Vaginal contractions. As in, almost to where she was having little orgasms just walking around the house. To say she was hot and flustered would be an understatement - she was in heat! 

 

If the kids had not been home at this time, I'm fairly confident we would have spent the whole night humping like teenagers. Sadly, I went to bed alone and had to take care of matters by myself (we have separate bedrooms due to snooring). This was something like six or seven hours after the injection. And that's where the trouble really started for me. I did my usual 20 minute PE routine and added a set of clamping after as usual, and then relieved myself... I was 100% hard the whole pumping set, and after my first ejaculation my penis just refused to settle down. 

 

Ok, that happens. Rarely, admittedly, at the venerable age of 52, but it happens. But what doesn't ever happen is that it wants to have a third round. That happened that night. And after the third one, it didn't take long for my erection to return. I have never felt anything like it! 

 

But I was tired, so I went to sleep with a raging boner. And all through the night, I had troubled dreams and woke up several times with a massive nocturnal erection that just refused to die down. Needless to say, morning glory was glorious, so PE that morning worked great. And these spontaneous erections didn't subside until lunchtime - almost 24 hours after the injection. My wife reported a very similar experience - her feeling of being aroused and swollen down there didn't subside until more than 24 hours had passed. The contractions lasted about six hours in total. 

 

So, what conclusions must I draw from this? Well, it's an f-ing phenomenal substance, is what it is. It does what it says on the bottle for sure. I can imagine using it for a weekend retreat with my wife, or for attending a play party with friends (I told you we're adventurous). I also think we will make a habit of using it quite frequently for our planned playtime. We have kids in the house almost all the time, and thin walls, and really prefer our privacy since we like to have loud and advanced sex which requires preparation, toys, various electrical implements, rope, paddles and whips, etc... But for planned playtime, my wife will use PT-141 from now on, and make sure to take it at least two or three hours in advance. 

 

I honestly don't feel I need it, since my libido is generally high enough, and since starting PE my erection quality is through the roof - especially since I take daily Cialis and L-Citrulline. But I will sometimes take PT-141 as well, just for fun. 

 

 

Now, please don't rush off and buy this drug without a prescription just because I did. I sometimes lack common sense, and I am not a good role model in these matters. But if you're in the US and your lady is premenopausal, consider this a strong endorsement! This is the aphrodisiac humanity has been trying to concoct for millennia. Thank you, Science!